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Morphine is a pure opioid agonist whose princi pal therapeutic action is analgesia. Other members of the class known as opioid agonist s include substances such as oxycodone, hydromorphone, fentanyl, codeine, and hydrocodone . Pharmacological effects of opioid agonists include anxiolysis, euphoria, feelings of relaxati on, respiratory depression, constipation, miosis, cough suppression, and analgesia. Like all pure opioid agonist analgesics, with increasing doses there is increasing analgesia, unlike with mi xed agonist/antagonists or non-opioid analgesics, where there is a limit to the analgesic effect with increasing doses. With pure opioid agonist analgesics, there is no defined maximum dose; the ceiling to analgesic effectiveness is imposed only by side effects, the more serious which ma y include somnolence and respiratory depression.