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After therapy is initiated, individually titrate OxyContin to a dose that provides an appropriate balance between pain relief and opioid-related side effects.
- Patients who experience breakthrough pain may need dosage adjustment or rescue medication
- OxyContin dose adjustments may be made every 1- 2 days
- The 12 -hour dosing interval should not be changed; it is most appropriate to increase the q12h dose, if analgesic goals are not being met and it is anticipated that side effects can be managed.
- The total daily dose can usually be increased by 25% to 50% of the current dose
- If significant adverse reactions occur, treat them aggressively until they are under control, then resume upward titration, if appropriate